They appear as old men adorned in ceremonial robes, and carry a magical scroll with them. Having the power to teleport, they can also drain Kratos' own magic. Additionally, they can create a small green tourbillon to ralent Kratos, and hurt him with green magic claws. With their scrolls, they can even summon additional monsters to their aid.
Kratos can inflict damage upon the priests by locking his blade with their scroll and defeating them in a power struggle, after the which he gives them an uppercut, sending them flying. After doing enough damage, Kratos initiates a final power struggle, and then kills the priests by impaling them in the back with one of his blades, and cutting their throats and decapitating them with the other.
Kratos only encounters the High Priests twice. Once in the Hall of Atropos, where they were known to mostly summon Minotaurs Grunts, and during Kratos' attempt to protect a Translator from harm, where they summoned Fates Guardians. Also, they appear in the sixth and seventh Challenge of the Titans, where they could summon Wild Cerberus, and Cyclops Berserker, respectively.